📗 -> 04/21/25: NPB173-L6
🎤 Vocab
❗ Unit and Larger Context
Review Up Until Now
Lecture 1: Overview
- Impact of brain disorders
- variety of levels of severity for and across disorders
- Not just the person, but the radius of impact on people around them
- Studying brain disorders from the complementary perspectives of neurology and psychiatry
- Psychiatric - Always involving the brain
- Neurological - Not always about the brain. Spinal injury, etc.
- Characterizing signs and symptoms of dysfunction to reach a diagnosis
- Symptom - 1st person
- Sign - 3rd person objective measure
- Diagnosis - A word/classification that can describe a disorder
- Pathophysiology
- What has gone awry in biological processes to underlie a particular disorder
- Connecting across multiple spatial scales/levels of analysis of the nervous system
- Familiar with terms across different levels
- Changing perspectives from diseased brain to healthy brain as a goal
- Use of model systems to better understand brain disorders
- Use of animal model and non-human model systems
- In vitro and in vivo, both beneficial
Lecture 2:
- Basic function of neurons and glia
- Astrocytes play a role in the BBB, and other roles as well (glial scar formation too)
- Oligodendrocytes and Schwann cells provide myelin
- Large scale division of the nervous system
- CNS vs PNS. Implications for brain function
- Difference in myelin providing cells, and BBB
- Subdivision in CNS:
- Cerebrum, thalamus, diencephalon, cerebellum, brain stem, spinal cord
- Segmented structure of the spinal cord
- Segmented structure of the spinal cord
- Major segments in the SC that correspond to different spinal nerves.
- Dermatomes for sensory system, myotomes for the motor system
- Grey matter vs white matter
- Grey matter on inside of the spinal cord (butterfly like)
- Where cell bodies reside (everything else too ofc)
- White matter consists almost entirely of axon bundles (outside of spinal cord)
- Need to know 3 tracts
- Grey matter on inside of the spinal cord (butterfly like)
- Dermatomes reveal vertical organization of spinal cord
- Dorsal/ventral (back/bely) organization of the spinal cord
- Rostral/Caudal
- Wallerian degeneration
- Biological response to injury. Active degeneration
- Kind of like a scab. Useful
- Axonal regeneration and differences between PNS and CNS
- Only the PNS can recover axon with proper route finding
- Not hard to regrow growth cone, but finding proper route can be hard. Schwann cells can guide this, form hollow tubes along path. (can be hard for long axons though)
- Deductive approach for inferring spinal injury based on symptoms and vice-versa
✒️ -> Scratch Notes
- Log as you go through entry
🧪 -> Refresh the Info
Did you generally find the overall content understandable or compelling or relevant or not, and why, or which aspects of the reading were most novel or challenging for you and which aspects were most familiar or straightforward?)
Did a specific aspect of the reading raise questions for you or relate to other ideas and findings you’ve encountered, or are there other related issues you wish had been covered?)
🔗 -> Links
Resources
- Put useful links here
Connections
- Link all related words