Content - Lecture 8-12
Huntington Disease
- Huntington’s Chorea: movements that can’t be controlled, called chorea
- Also brain damage and affects movement, cognition, and behavior
- Huntintin - >36 safe, 36-39 risk, 40 will have
- CAG repeats (glutamine)
- Over cleavage, forming Huntington’s Neural Inclusions
- Damage to striatal circuits
- indirect circuit damage thought to be responsible for chorea and control
- Direct circuit damage thought to be responsible for fine motor control and rigidity
Parkinson Disease
- Bradykinesia, signature turn
- SNCA gene, alpha-synuclein protein, and Lewy bodies
- Death of dopaminurgic neurons in SNc
- Less excitation to direct and indirect, net inhibition
Alzheimer Disease and other dementias - Mild cognitive impairment, severe cognitive impairment -> dementias
- Alzheimer: amyloid plaque or tau
- leads to
Amyotrophic Lateral Sclerosis
- leads to
- Upper/lower motor neurons
- do we even know??
- Degradation
Review and synthesis of concepts in Section 2